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TORONTO, ON / ACCESSWIRE / October 7, 2020 / Monterey Minerals Inc. (the "Company" or "Monterey") (CSE:MREY)(FSE:2DK) is pleased to announce that drilling has commenced at Monterey's wholly-owned Alicia high-grade gold and base metals project in Alicia Municipality, Philippines ("Alicia Project"). With the commencement of drilling, the Company will execute an initial 3,000 metre program. The drilling targets will focus on the high-grade gold and polymetallic Pamaraw, Baloy, Sandi and Quintilla veins which have been identified over the 10 kilometres of strike length at Alicia. "We look forward to putting our exploration theories to the test with our drilling program. Our view is that some of the veins previously identified could merge at depth and generate a larger, higher grade system. We will continue to update the market throughout the fourth quarter of this year with results", stated James Macintosh, President and CEO. Qualified Person The technical information in this press release has been reviewed and approved by Martin Dormer, a consultant to the Company, who is a Qualified Person as defined by NI 43-101. Martin is a member of the Australian Institute of Mining and Metallurgy (AusIMM), the Australian Institute of Geoscientists (AIG). He is a West Australian geologist with over 22 years' experience and sufficient experience of relevance to the styles of mineralization and types of deposits under consideration to qualify as a Competent Person as defined by the 2012 Edition of the Joint Ore Reserves Committee (JORC) Australian Code for Reporting of Exploration Results, Mineral Resources, and Ore Reserves. About Monterey Minerals Inc. The Company owns 100% of the Alicia Project in the Alicia Municipality of the Philippines. The Alicia Project is a system of multiple, high-grade gold and silver veins with base metals over a strike length of greater than ten kilometres. The Company also owns the Cobalt Mountain Property (the "Property") in the Omineca Mining Division of British Columbia near the town of Smithers. The Company's NI 43-101 technical report, available on SEDAR, notes historic sampling on the Property that returned mineralized showings of gold, silver, copper, zinc and cobalt. The Company also owns 877 sq. km. of prospective Pilbara Basin tenements on the eastern flank of the Pilbara Basin in Western Australia. For more information, contact investor relations at info@montereyminerals.com On Behalf of the Board of Directors, James Macintosh, President and CEO Neither the Canadian Securities Exchange nor its regulation services provider has reviewed or accepted responsibility for the adequacy or accuracy of this press release This press release may include forward-looking information within the meaning of Canadian securities legislation, concerning the business of the Company. Forward-looking information is based on certain key expectations and assumptions made by the management of the Company. Although the Company believes that the expectations and assumptions on which such forward-looking information is based on are reasonable, undue reliance should not be placed on the forward-looking information because the Company can give no assurance that they will prove to be correct. Forward-looking statements contained in this press release are made as of the date of this press release. The Company disclaims any intent or obligation to update publicly any forward-looking information, whether as a result of new information, future events or results or otherwise, other than as required by applicable securities laws. SOURCE #Mining #Gold #GoldMining #GoldExploration #HighGradeGold #GoldStocks #InvestingingGold #MiningStocks #SmallCapStocks #FrontierMCG

KABN North America Announces Hiring of Mackie Research Capital Corporation for Capital Markets Services Not for Distribution to U.S. News Wire Services or for Dissemination in the U.S. TORONTO, ON / ACCESSWIRE /  November 11, 2020 / KABN Systems NA Holdings Corp. (CSE:KABN) (the "Company" or "KABN North America" or "KABN NA"), a Canadian Fintech company that specializes in continuous online identity verification, management and monetization in Canada and the U.S., is pleased to announce that it has engaged Mackie Research Capital Corporation ("Mackie") as a financial and capital markets advisor to the Company. The service agreement includes providing advice and assistance in connection with defining strategic and financial objectives, making initial contacts with potential institutional and strategic investors, maintaining a regular dialogue with the Company in regards to corporate development, strategic growth objectives as well as general market sentiment, assist in maintaining an orderly and liquid market in the Company's shares and increasing market awareness of KABN North America. KABN North America has agreed to retain Mackie as its Canadian financial advisor for a term of twelve (12) months ending November 10, 2021, and the arrangement may be extended by mutual agreement. "We are very excited to be working with the Mackie team to extend our reach in the Canadian public marketplace," said David Lucatch, CEO of KABN NA. "We believe that this relationship will create additional value for the Company and our stakeholders." As part of the compensation for its services, Mackie will receive a monthly fee of $6,500 for its trading advisory services for a minimum of 6 months with extension by mutual agreement and a financial advisory fee of $75,000 payable in common shares in the capital of the Company at a deemed price equal to $0.15 per common share. In addition, The Company will grant 1,500,000 common share purchase warrants (the "Broker Warrants") to Mackie Research. Each Broker Warrant will entitle the holder thereof to purchase one common share in the capital of the Company at an exercise price of $0.20 at any time up to 24 months following the date of issuance. The issuance including, but not limited to, the price of the common shares and warrants is subject to the rules of the Canadian Securities Exchange and remains subject to applicable regulatory approvals. About Mackie Research Capital Corporation Macie Research Capital Corporation is one of Canada's largest independent full servicce investment firms, and proudly traces its roots back to 1921. Mackie Research is privately owned by many of its 300 employees. As a fully integrated national investment dealer, Mackie Research offers a full complement of capital markets and wealth managment services to private clients, institutions and growth companies. About KABN North America - www.kabnnaholdco.com KABN Systems NA Holdings Corp. through its wholly owned subsidiary KABN Systems North America Inc. focuses on the verification, management and monetization of digital identity, empowering users to control and benefit from its use of their online identity. KABN NA's propriety technology suite includes 4 key products: Liquid Avatar allows users to create high quality digital icons representing their online personas. These icons, in conjunction with KABN ID, allows users to manage and control their Digital Identity and to use Liquid Avatars to share public and permission based private data when they want and with whom they want. www.liquidavatar.com KABN ID is an Always On, biometric and blockchain based digital identity validation and verification platform allowing users to continuously and confidently prove themselves throughout the online community. KABN Card is a Visa approved prepaid card program allowing users to manage both digital and fiat currencies and earn cashback and other loyalty incentives. www.kabncard.com KABN KASH is a cashback, loyalty and engagement program that powers the KABN NA's revenue ecosystem. KABN NA provides its products and services at no cost to consumers and generates revenues through permission-based partner programs. www.kabnkash.com For more information, please visit www.kabnnaholdco.com or www.kabnsystemsna.com For further information, please contact: David Lucatch 647-725-7742 Ext. 701 ir@kabnsystemsna.com The CSE has not reviewed and does not accept responsibility for the adequacy or accuracy of this release. This news release does not constitute an offer to sell, or a solicitation of an offer to buy, any securities under the KABN Financing in the United States. The securities have not been and will not be registered under the United States Securities Act of 1933, as amended (the "U.S. Securities Act") or any state securities laws and may not be offered or sold within the United States or to U.S. Persons unless registered under the U.S. Securities Act and applicable state securities laws or an exemption from such registration is available. Forward-Looking Information and Statements This press release contains certain "forward-looking information" within the meaning of applicable Canadian securities legislation and may also contain statements that may constitute "forward-looking statements" within the meaning of the safe harbor provisions of the United States Private Securities Litigation Reform Act of 1995. Such forward-looking information and forward-looking statements are not representative of historical facts or information or current condition, but instead represent only the Company's beliefs regarding future events, plans or objectives, many of which, by their nature, are inherently uncertain and outside of the Company's control. Generally, such forward-looking information or forward-looking statements can be identified by the use of forward-looking terminology such as "plans", "expects" or "does not expect", "is expected", "budget", "scheduled", "estimates", "forecasts", "intends", "anticipates" or "does not anticipate", or "believes", or variations of such words and phrases or may contain statements that certain actions, events or results "may", "could", "would", "might" or "will be taken", "will continue", "will occur" or "will be achieved". The forward-looking information and forward-looking statements contained herein may include, but is not limited to, information concerning the ability of the Company to generate revenues, roll out new programs and to successfully achieve business objectives, including to accelerate the Company's development, customer acquisition and business platform, and expectations for other economic, business, and/or competitive factors. By identifying such information and statements in this manner, the Company is alerting the reader that such information and statements are subject to known and unknown risks, uncertainties and other factors that may cause the actual results, level of activity, performance or achievements of the Company to be materially different from those expressed or implied by such information and statements. In addition, in connection with the forward-looking information and forward-looking statements contained in this press release, the Company has made certain assumptions. Among the key factors that could cause actual results to differ materially from those projected in the forward-looking information and statements are the following: changes in general economic, business and political conditions, including changes in the financial markets; changes in applicable laws; compliance with extensive government regulation. Should one or more of these risks, uncertainties or other factors materialize, or should assumptions underlying the forward-looking information or statements prove incorrect, actual results may vary materially from those described herein as intended, planned, anticipated, believed, estimated or expected. Although the Company believes that the assumptions and factors used in preparing, and the expectations contained in, the forward-looking information and statements are reasonable, undue reliance should not be placed on such information and statements, and no assurance or guarantee can be given that such forward-looking information and statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such information and statements. The forward-looking information and forward-looking statements contained in this press release are made as of the date of this press release, and the Company does not undertake to update any forward-looking information and/or forward-looking statements that are contained or referenced herein, except in accordance with applicable securities laws. SOURCE #Technology #DisruptiveTechnology #KYC #AML #OnlineIdentity #PersonalData #OwnYourData #Data #OnlineSecurity #DataSecurity #DataProtection #GDPR #FinancialServices #DigitalWallet #Blockchain #Fintech #LiquidAvatar #InvestinginTech #TechStocks #FintechStocks #FrontierMCG

Algernon Begins Screening Patients for Phase 2 Ifenprodil IPF and Chronic Cough Human Study in Australia VANCOUVER, British Columbia, July 07, 2020 (GLOBE NEWSWIRE) -- Algernon Pharmaceuticals Inc. (CSE: AGN) (FRANKFURT: AGW) (OTCQB: AGNPF) (the “Company” or “Algernon”) a clinical stage pharmaceutical development company, is pleased to announce that it has begun screening patients for suitability for enrolment in its Phase 2 idiopathic pulmonary fibrosis (IPF) and chronic cough clinical study of its re-purposed drug NP-120 (Ifenprodil). Ifenprodil is an NMDA receptor antagonist specifically targeting the NMDA-type subunit 2B. There are 5 sites in total participating in the study with 3 located in Australia and 2 in New Zealand. All 5 sites have now received ethics approval and all have successfully completed their site initiation. The Company originally decided to investigate Ifenprodil for both IPF and chronic cough after conducting several animal studies that showed the drug’s superior activity when compared with current standard of care treatments and a leading Phase 3 drug. IPF Animal Study Summary Ifenprodil showed superiority in reducing fibrosis over two globally approved therapies for IPF, Roche’s Pirfenidone and Boehringer Ingelheim’s Nintedanib, in a well-established in vivo animal model study. Data from this study showed a 56.0% reduction in fibrosis vs untreated controls (p=0.015) in a 21-day bleomycin mouse model (treatment began on Day 7). Chronic Cough Animal Study Summary Ifenprodil outperformed Merck’s Phase 3 Drug MK-7264 (Gefapixant) in an Acute Cough Study by 110%, in a well-accepted acute cough in-vivo animal study. Pharmidex, a contract research organization (CRO) and a global leader in respiratory research conducted the cough study using the guinea pig citric acid challenge model. It should also be noted that unlike Gefapixant, Ifenprodil has no known taste disturbance. “There has been a significant amount of news flow recently related to our Ifenprodil COVID clinical trial program,” said Christopher J. Moreau, CEO of Algernon Pharmaceuticals. “However, while this is still an important focus for the company, this is a very appropriate time to remind our shareholders that Ifenprodil was initially selected for advancement into a human clinical trial based on its strong animal data for IPF and chronic cough. These are also important areas with significant unmet clinical needs. We look forward to updating the market when our first patient has been enrolled.“ About NP-120 (Ifenprodil) NP-120 (Ifenprodil) is an N-methyl-D-aspartate (NMDA) receptor antagonist specifically targeting the NMDA-type subunit 2B (Glu2NB). Ifenprodil prevents glutamate signalling. The NMDA receptor is found on many tissues including lung cells and T-cells, neutrophils. About Algernon Pharmaceuticals Inc. Algernon is a drug re-purposing company that investigates safe, already approved drugs for new disease applications, moving them efficiently and safely into new human trials, developing new formulations and seeking new regulatory approvals in global markets. Algernon specifically investigates compounds that have never been approved in the U.S. or Europe to avoid off label prescription writing. Algernon has filed new intellectual property rights globally for NP-120 (Ifenprodil) for the treatment of respiratory diseases and is working to develop a proprietary injectable and slow release formulation. CONTACT INFORMATION Christopher J. Moreau CEO Algernon Pharmaceuticals Inc. 604.398.4175 ext 701 info@algernonpharmaceuticals.com investors@algernonpharmaceuticals.com www.algernonpharmaceuticals.com The CSE does not accept responsibility for the adequacy or accuracy of this release. Neither the Canadian Securities Exchange nor its Market Regulator (as that term is defined in the policies of the Canadian Securities Exchange) accepts responsibility for the adequacy or accuracy of this release. The Canadian Securities Exchange has not in any way passed upon the merits of the proposed transaction and has neither approved nor disapproved the contents of this press release. CAUTIONARY DISCLAIMER STATEMENT: No Securities Exchange has reviewed nor accepts responsibility for the adequacy or accuracy of the content of this news release. This news release contains forward-looking statements relating to product development, licensing, commercialization and regulatory compliance issues and other statements that are not historical facts. Forward-looking statements are often identified by terms such as “will”, “may”, “should”, “anticipate”, “expects” and similar expressions. All statements other than statements of historical fact, included in this release are forward-looking statements that involve risks and uncertainties. There can be no assurance that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Important factors that could cause actual results to differ materially from the Company’s expectations include the failure to satisfy the conditions of the relevant securities exchange(s) and other risks detailed from time to time in the filings made by the Company with securities regulations. The reader is cautioned that assumptions used in the preparation of any forward-looking information may prove to be incorrect. Events or circumstances may cause actual results to differ materially from those predicted, as a result of numerous known and unknown risks, uncertainties, and other factors, many of which are beyond the control of the Company. The reader is cautioned not to place undue reliance on any forward-looking information. Such information, although considered reasonable by management at the time of preparation, may prove to be incorrect and actual results may differ materially from those anticipated. Forward-looking statements contained in this news release are expressly qualified by this cautionary statement. The forward-looking statements contained in this news release are made as of the date of this news release and the Company will update or revise publicly any of the included forward-looking statements as expressly required by applicable law. #Technology #MedicalTechnology #Medtech #DrugDiscovery #MedicalResearch #MedicalDevices #PharmaceuticalDevelopment #BreathAnalysis #FAIMS #DrugRepurosing #RespiratoryMedicine #RespiratoryIllness #ClinicalTrials #HumanTrials #MedicalTechnology #MedicalAdvancements #DrugDevelopment #Research #MedicalBreakthrough #Coronavirus #COVID19 #Biotech #BiotechStocks #InvestinginHealthcare #InvestinginMedicine #SmallCapStocks #FrontierMCG

VANCOUVER, British Columbia, July 21, 2020 (GLOBE NEWSWIRE) -- Algernon Pharmaceuticals Inc. (CSE: AGN) (FRANKFURT: AGW) (OTCQB: AGNPF) (the “Company” or “Algernon”) a clinical stage pharmaceutical development company, is pleased to highlight an independent research study (the “Study”) from UT Dallas’ Center for Advanced Pain Studies, that identified Ifenprodil as one of a number of possible drug candidates for the treatment of COVID -19. The Study was recently published online on June 1, 2020 in Brain, Behaviour, and Immunity. The Study identified interactions between the immune system and nerves in the lungs that can cause rapid deterioration in COVID-19 patients. The authors looked at the relative gene abundance in the lungs of COVID-19 patients compared to the lungs of healthy controls. In addition to genes that might be expected to be upregulated, the levels of the gene that expressed the NMDA GluN2B receptor in immune cells were also greatly increased. In an article written by Stephen Fontenot from The University of Texas at Dallas, Dr. Theodore Price, one of the co-authors of the study, suggested that interrupting the interaction between the NMDA receptor and glutamate, one of the neurotransmitters that NMDA receptors respond to, could lessen the damage caused by the infection. Ifenprodil is an NMDA receptor antagonist specifically targeting the GluN2B subunit, preventing glutamate signalling. The NMDA receptor is found on many tissues including lung cells, T-cells, and neutrophils. The Company believes that Ifenprodil may reduce the infiltration of neutrophils and T-cells into the lungs where they can release glutamate and cytokines respectively. The latter can result in the highly problematic cytokine storm that contributes to the loss of lung function and ultimately death as has been reported in COVID-19 infected patients. In a recent conversation with the Company, Dr. Theodore Price said, “We were really taken aback at the upregulation of NMDA receptors in severe COVID-19 patients. We were even more surprised, when we noted that it was an immune based signal and not neuronal. Based on our findings, we think there is significant opportunity in disrupting NMDA receptor signalling in the lung for reversing pathology in COVID.” “This study provides significant additional data to what we have already identified, suggesting that Ifenprodil may be an effective treatment for COVID-19,” said Christopher J. Moreau, CEO of Algernon Pharmaceuticals. Article link:https://www.utdallas.edu/news/healthmedicine/nerve-cells-lungs-covid-19-2020/ Research study link: https://linkinghub.elsevier.com/retrieve/pii/S088915912030670X Background The Company announced on March 06, 2020 that it was going to explore Ifenprodil as a possible treatment for COVID-19 when it discovered an independent research study that showed the drug was active in an animal model for H5N1, the world’s most lethal avian flu, with an approximately 60% mortality rate in humans. In the study, Ifenprodil reduced mortality by 40% and reduced acute lung injury and inflammation in the lung tissue. Coupled with the Company’s own animal data showing Ifenprodil’s reduction of lung fibrosis in two separate studies, the Company is investigating Ifenprodil to determine if it can reduce the severity and duration of a COVID infection. The Company is about to begin a multinational Phase 2b/3 human trial for COVID-19 entitled, "A Randomized Open Label Phase 2b/3 Study of the Safety and Efficacy of NP-120 (Ifenprodil) for the Treatment of Hospitalized Patients with Confirmed COVID-19 Disease."  Westchester Research Center at Westchester General Hospital in Miami, Florida was recently announced as the first U.S. clinical site participating in the study. About Algernon Pharmaceuticals Inc. Algernon is a drug re-purposing company that investigates safe, already approved drugs for new disease applications, moving them efficiently and safely into new human trials, developing new formulations and seeking new regulatory approvals in global markets. Algernon specifically investigates compounds that have never been approved in the U.S. or Europe to avoid off label prescription writing. Algernon has filed new intellectual property rights globally for NP-120 (Ifenprodil) for the treatment of respiratory diseases and is working to develop a proprietary injectable and slow release formulation. CONTACT INFORMATION Christopher J. Moreau CEO Algernon Pharmaceuticals Inc. 604.398.4175 ext 701 info@algernonpharmaceuticals.com investors@algernonpharmaceuticals.com www.algernonpharmaceuticals.com The CSE does not accept responsibility for the adequacy or accuracy of this release. Neither the Canadian Securities Exchange nor its Market Regulator (as that term is defined in the policies of the Canadian Securities Exchange) accepts responsibility for the adequacy or accuracy of this release. The Canadian Securities Exchange has not in any way passed upon the merits of the proposed transaction and has neither approved nor disapproved the contents of this press release. CAUTIONARY DISCLAIMER STATEMENT: No Securities Exchange has reviewed nor accepts responsibility for the adequacy or accuracy of the content of this news release. This news release contains forward-looking statements relating to product development, licensing, commercialization and regulatory compliance issues and other statements that are not historical facts. Forward-looking statements are often identified by terms such as “will”, “may”, “should”, “anticipate”, “expects” and similar expressions. All statements other than statements of historical fact, included in this release are forward-looking statements that involve risks and uncertainties. There can be no assurance that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Important factors that could cause actual results to differ materially from the Company’s expectations include the failure to satisfy the conditions of the relevant securities exchange(s) and other risks detailed from time to time in the filings made by the Company with securities regulations. The reader is cautioned that assumptions used in the preparation of any forward-looking information may prove to be incorrect. Events or circumstances may cause actual results to differ materially from those predicted, as a result of numerous known and unknown risks, uncertainties, and other factors, many of which are beyond the control of the Company. The reader is cautioned not to place undue reliance on any forward-looking information. Such information, although considered reasonable by management at the time of preparation, may prove to be incorrect and actual results may differ materially from those anticipated. Forward-looking statements contained in this news release are expressly qualified by this cautionary statement. The forward-looking statements contained in this news release are made as of the date of this news release and the Company will update or revise publicly any of the included forward-looking statements as expressly required by applicable law. #Technology #MedicalTechnology #Medtech #DrugDiscovery #MedicalResearch #MedicalDevices #PharmaceuticalDevelopment #BreathAnalysis #FAIMS #DrugRepurosing #RespiratoryMedicine #RespiratoryIllness #ClinicalTrials #HumanTrials #MedicalTechnology #MedicalAdvancements #DrugDevelopment #Research #MedicalBreakthrough #Coronavirus #COVID19 #Biotech #BiotechStocks #InvestinginHealthcare #InvestinginMedicine #SmallCapStocks #FrontierMCG

Orchid Ventures Announces Second Record Month in a Row with Over 100% Growth and $2MM in Purchase Orders IRVINE, Calif., July 28, 2020 (GLOBE NEWSWIRE) -- ORCHID VENTURES, INC. (CSE: ORCD OTC: ORVRF) (the “Company” or “Orchid”), a multi-state cannabis innovation company, is pleased to announce that, for the second month in a row, the Company has continued to set purchase order records totalling over $2MM CAD, or over 100% month-over-month growth. On July 23, 2020, through its wholly owned subsidiary, PurTec Delivery Systems, the Company received purchase orders from both its licensee in Oregon and from other substantial PurTec customers. The orders are for PurTec’s innovative PurCore Summit cartridge which is a direct competitor to C-Cell, but with several engineering enhancements and the only hardware delivery system that is emissions tested to meet AFNOR safety standards. PurTec is also driving significant revenue from eco-friendly, plastic free, wind energy manufactured child resistant retail packaging cartons. In addition, the company has seen its licensee in Oregon start to successfully ramp up the Orchid business and with the company’s newly developed infrastructure for California they are making strong progress in expanding their footprint, building inventory and growing revenue. “This is a huge step for our organization and further validation that the fundamental shifts we have undertaken as a company are setting us on a course of accelerated growth and profitability. Our focus has been on rebuilding the company by diversifying the business, commercializing new product innovation and expanding the Orchid brand through our licensing model. We are confident that this strategic direction will lead to continued growth opportunities and ultimately positive cash flow and incremental profits. To me, it has been most rewarding to see the energy, enthusiasm and dedication that everyone at Orchid has demonstrated to build the momentum that we are now experiencing. I am proud to be part of this exceptional group of people and excited to see our vision for the business start to unfold,” said Corey Mangold, Founder & CEO. “Since the downturn in the cannabis public markets, and Vape-Gate 2019, we have kept our heads down, and developed two subsidiaries without further dilution or adding additional debt. The fact that we are generating meaningful cash flows, and servicing our existing obligations, is a huge turning point in our evolution in becoming a profitable and innovative company. I’m excited for our shareholders and for our vision as a company.” The Company has granted a total of 6,250,000 stock options to its officers and employees in accordance with the Company’s equity incentive plan. Each stock option is exercisable at a price of $0.06 per share for a period of 5 years. The Company has cancelled 1,750,000 stock options that were granted in March 2019 at a price of $0.33 per share. The Company also announces that its Chief Operating Officer, Eric Vaughan, has taken a leave of absence. During this time and upon his return, Mr. Vaughan will act as a consultant to the Company. Investors are reminded of the upcoming conference call scheduled for 11am PDT on July 28, 2020. Dial-in information is listed below. Orchid Ventures Investor Update Call Date: July 28, 2020 Time: 11:00 a.m. PDT Toll Free: 844-407-9500 International: 862-298-0850 Replay Dial In: (replay expiration Tuesday, August 04, 2020) Toll Free: 877-481-4010 International: 919-882-2331 Replay Passcode: 35713 ABOUT ORCHID ESSENTIALS Orchid Essentials is an Irvine, CA-based cannabis innovation company, that launched in Oregon and California in August 2017 and has since developed a mass-market brand and loyal consumer following with its premium cannabis products and unique vape hardware delivery system. Since July 2019, Orchid has diversified its efforts and has brought to market innovative services and product offerings to support brands throughout the global cannabis industry. Orchid has diversified its portfolio to include PurTec Delivery Systems, a company that produces, markets and sells clean vaporizer hardware that has been emissions tested against the most stringent standards in the world set forth by the EU and has unrivaled product quality and value pricing. Orchid, through its wholly owned subsidiary, has launched a patented and clinically proven bioavailability solution to increase the absorption of THC and other cannabinoids making products much more effective and an activation time of less than ten minutes. With a continued focus on brand and intellectual property development, Orchid will continue to create new and innovative products and technologies, then bring them to the global cannabis marketplace and set the gold standard for delivery systems whether it’s vape or formulation sciences. Orchid's management brings significant branding, product development and distribution experience with a proven track record of scaling businesses and building sustainable revenue growth through value-generating partnerships and innovation that creates enterprise value. Learn more at https://orchidessentials.com/ ON BEHALF OF THE BOARD OF DIRECTORS – ORCHID VENTURES, INC. Corey Mangold CEO and Director investors@orchidessentials.com Investor Relations Corey Mangold 949-357-5818 corey@orchidessentials.com The CSE does not accept responsibility for the adequacy or accuracy of this release. Safe Harbor Statement Except for historical information contained herein, statements in this release may be forward-looking and made pursuant to the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. Words such as “anticipate”, “believe”, “estimate”, “expect”, “intend” and similar expressions, as they relate to Orchid Ventures, Inc. and Orchid Essentials any of its affiliates or subsidiaries (collectively, the “Company”) or its management, identify forward-looking statements. These statements are based on current expectations, estimates and projections about the Company's business based, in part, on assumptions made by management. These statements are not guarantees of future performance and involve risks, uncertainties, and assumptions that are difficult to predict. Therefore, actual outcomes and results may, and probably will, differ materially from what is expressed or forecasted in such forward-looking statements due to numerous factors, including those described above and those risks discussed from time to time in the Company’s Canadian securities regulatory filings with sedar.com, Factors which could cause actual results to differ materially from these forward-looking statements include such factors as (i) the development and protection of our brands and other intellectual property, (ii) the need to raise capital to meet business requirements, (iii) significant fluctuations in marketing expenses, (iv) the ability to achieve and expand significant levels of revenues, or recognize net income, from the sale of our products and services, (v) the Company’s ability to conduct the business if there are changes in laws, regulations, or government policies related to cannabis, (vi) management’s ability to attract and maintain qualified personnel necessary for the development and commercialization of its planned products, and (vii) other information that may be detailed from time to time in the Company’s Canadian securities regulatory filings with sedar.com. The Company undertakes no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. SOURCE #Cannabis #Vapes #CannabisAccessories #CannabisProducts #CannabisMarket #Cannabinoids #THC #CBD #CBDProducts #CannabisResearch #CannabinoidResearch #CBDResearch #EndocannabinoidMedicine #PotStocks #Cannabiz #CannabisMarket #CannabisStocks #Patents #PatentTechnology #CannabisTechnology #SmallCapStocks #FrontierMCG

Revive Therapeutics Update Following U.S. FDA Approval of Phase 3 Clinical Trial for Bucillamine in COVID-19 TORONTO, Aug. 05, 2020 (GLOBE NEWSWIRE) -- Revive Therapeutics Ltd. (“Revive” or the “Company”) (CSE: RVV, USA: RVVTF), a specialty life sciences company focused on the research and development of therapeutics for medical needs and rare disorders, is pleased to announce that following the U.S. Food & Drug Administration (“U.S. FDA”) approval to proceed with the Company’s Phase 3 clinical trial to evaluate the safety and efficacy of Bucillamine in patients with mild-moderate COVID-19, the Company is finalizing agreements and aligning resources to initiate the Phase 3 clinical trial in September. “With the FDA approval of the Phase 3 clinical study to evaluate Bucillamine in the treatment of patients with mild-moderate COVID-19, our team and partners are working diligently to align our resources and expertise that will fast-track the Phase 3 study,” said Michael Frank, Revive’s Chief Executive Officer. Revive expects to engage up to 10 clinical trial sites in the U.S. and open the Phase 3 clinical trial for patient screening in Q3-2020.  The Company is finalizing vendor agreements in the project management, medical monitoring, data management and clinical packaging for the  trials.  In addition, Revive and its clinical trial partners will be evaluating potential U.S. clinical sites and clinical  investigators in major COVID-19 affected U.S. states, such as Florida, California, Arizona and Texas. About the Phase 3 Confirmatory Clinical Study The Phase 3 confirmatory clinical study titled, “A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study of Bucillamine in Patients with Mild-Moderate COVID-19”, will enroll up to 1,000 patients that will be randomized 1:1:1 to receive Bucillamine 100 mg three times a day (“TID”), Bucillamine 200 mg TID or placebo TID for up to 14 days.  The primary objective is to compare frequency of hospitalization or death in patients with mild-moderate COVID-19 receiving Bucillamine therapy with those receiving placebo.  The primary endpoint is the proportion of patients meeting a composite endpoint of hospitalization or death from the time of first dose through Day 28 following randomization.  Efficacy will be assessed by comparison of clinical outcome (death or hospitalization), disease severity using the 8-category NIAID COVID ordinal scale, supplemental oxygen use, and progression of COVID‑19 between patients receiving standard-of-care plus Bucillamine (high dose and/or low dose) and patients receiving standard-of-care plus placebo.  Safety will be assessed by reported pre-treatment adverse events and treatment-emergent adverse events (including serious adverse events and adverse events of special interest), laboratory values (hematology and serum chemistry), vital signs (heart rate, respiratory rate, and temperature), and peripheral oxygen saturation. An interim analysis will be performed by an Independent Data and Safety Monitoring Board (“DSMB”) after 210 patients have been treated and followed up for a total of 28 days after randomization.  The better performing Bucillamine dose at the interim analysis will be selected and patients will then be randomized 2:1 to the selected Bucillamine dose or placebo. Additional interim analyses will be performed after 400, 600, and 800 patients have reached this same post-treatment timepoint.  The independent DSMB will actively monitor interim data for the ongoing safety of patients and will recommend continuation, stopping or changes to the conduct of the study based on the interim analysis reports. The Company is not making any express or implied claims that its product has the ability to eliminate or cure COVID-19 (SARS-2 Coronavirus) at this time. Scientific Rationale of Bucillamine for COVID-19 Preclinical and clinical studies have demonstrated that reactive oxygen species contribute to the destruction and programmed cell death of pulmonary epithelial cells.1 N-acetyl-cysteine (NAC) has been shown to significantly attenuate clinical symptoms in respiratory viral infections in animals and humans, primarily via donation of thiols to increase antioxidant activity of cellular glutathione2,3,4,5. Bucillamine (N-(mercapto-2-methylpropionyl)-l-cysteine) has a well-known safety profile and is prescribed in the treatment of rheumatoid arthritis in Japan and South Korea for over 30 years. Bucillamine, a cysteine derivative with two thiol groups, has been shown to be 16 times more potent as a thiol donor in vivo than NAC 6. The drug is non-toxic with high cellular permeability. The basis of the clinical study will analyze if Bucillamine has the potential, via increasing glutathione activity and other anti-inflammatory activity, to lessen the destructive consequences of SARS-CoV2 infection in the lungs and attenuate the clinical course of COVID-19. About Revive Therapeutics Ltd. Revive is a life sciences company focused on the research and development of therapeutics for infectious diseases and rare disorders, and it is prioritizing drug development efforts to take advantage of several regulatory incentives awarded by the FDA such as Orphan Drug, Fast Track, Breakthrough Therapy and Rare Pediatric Disease designations. Currently, the Company is exploring the use of Bucillamine for the potential treatment of infectious diseases, with an initial focus on severe influenza and COVID-19. With its recent acquisition of Psilocin Pharma Corp., Revive is advancing the development of Psilocybin-based therapeutics in various diseases and disorders. Revive’s cannabinoid pharmaceutical portfolio focuses on rare inflammatory diseases and the Company was granted FDA orphan drug status designation for the use of Cannabidiol (CBD) to treat autoimmune hepatitis (liver disease) and to treat ischemia and reperfusion injury from organ transplantation.  For more information, visit www.ReviveThera.com. For more information, please contact: Michael Frank Chief Executive Officer Revive Therapeutics Ltd. Tel: 1-888-901-0036 Email: mfrank@revivethera.com Website: www.revivethera.com Neither the Canadian Securities Exchange nor its Regulation Services Provider have reviewed or accept responsibility for the adequacy or accuracy of this release Cautionary Statement This press release contains ‘forward-looking information’ within the meaning of applicable Canadian securities legislation. These statements relate to future events or future performance. The use of any of the words “could”, “intend”, “expect”, “believe”, “will”, “projected”, “estimated” and similar expressions and statements relating to matters that are not historical facts are intended to identify forward-looking information and are based on Revive’s current belief or assumptions as to the outcome and timing of such future events. Forward looking information in this press release includes information with respect to the Offering, including the intended use of proceeds. Forward-looking information is based on reasonable assumptions that have been made by Revive at the date of the information and is subject to known and unknown risks, uncertainties, and other factors that may cause actual results or events to differ materially from those anticipated in the forward-looking information. Given these risks, uncertainties and assumptions, you should not unduly rely on these forward-looking statements. The forward-looking information contained in this press release is made as of the date hereof, and Revive is not obligated to update or revise any forward-looking information, whether as a result of new information, future events or otherwise, except as required by applicable securities laws. The foregoing statements expressly qualify any forward-looking information contained herein. Reference is made to the risk factors disclosed under the heading “Risk Factors” in the Company’s annual MD&A for the fiscal year ended June 30, 2019, which has been filed on SEDAR and is available under the Company’s profile at www.sedar.com. References 1. S Ye et al, Inhibition of Reactive Oxygen Species Production Ameliorates Inflammation Induced by Influenza A Viruses via Upregulation of SOCS1 and SOCS3., American Society for Microbiology. 2015 Mar;89(5):2672-2683). 2. L. Carati et al, Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment., Eur Respir J. 1997 Jul;10(7):1535-41). 3. M Mata et al, N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV)., Biochem Pharmacol. 2011 Sep;82(5):548-55. 4. D Ungheri et al, Protective effect of n-acetylcysteine in a model of influenza infection in mice., Int J Immunopathol Pharmacol. 2000 Sep-Dec;13(3):123-128. 5. RH Zhang et al, N-acetyl-l-cystine (NAC) protects against H9N2 swine influenza virus-induced acute lung injury., Int Immunopharmacol. 2014 Sep;22(1):1-8). 6. LD Horwitz, Bucillamine: a potent thiol donor with multiple clinical applications, Cardiovasc Drug Rev. 2003 Summer;21(2):77-90). SOURCE #LifeSciences #AlternativeMedicine #DrugRepurposing #DrugDevelopment #Pharmaceuticals #PharmaceuticalSector #MedicalTechnology #Bucillamine #Influenza #Covid #InfectiousDiseases #InflammatoryDiseases #Research #MedicalResearch #MedTech #InvestinginMedicine #BiotechStocks #SmallCapStocks #FrontierMCG

Apabetalone’s Positive Impact on Pulmonary Arterial Hypertension Published in the American Journal of Respiratory and Critical Care Medicine CALGARY, Alberta, March 17, 2022 (GLOBE NEWSWIRE) -- Resverlogix Corp. ("Resverlogix") (TSX:RVX) today announced the publication of an article entitled “BET Protein Inhibition for Pulmonary Arterial Hypertension: A Pilot Clinical Study” in the prestigious American Journal of Respiratory and Critical Care Medicine – which has an impact factor of 21.4. The article outlines the positive impact of apabetalone in the investigator-led pulmonary arterial hypertension (PAH) pilot study, APPRoAcH-p. The article can be found HERE “The encouraging results published today highlight the potential benefit of BET protein inhibition, such as Resverlogix’s apabetalone, as a therapeutic strategy for PAH,” said Dr. Steeve Provencher, Director of Pulmonary Research, Quebec Heart and Lung Institute, Laval University, and the lead author of the article. “We are excited to be moving forward with a larger trial of apabetalone in PAH patients.” Publication Highlights Include: All patients completed the 16-week trial without discontinuation or dose reduction, suggesting that apabetalone was well tolerated in the study population Patients treated with apabetalone exhibited a reduction in pulmonary vascular resistance (PVR) at 16 weeks, the key exploratory efficacy endpoint of the study Apabetalone treatment was also associated with improved cardiac output (CO) and stroke volume (SV) over the 16-week treatment course “The APPRoAcH pilot study showed the potential benefit that apabetalone can offer for PAH patients,” said Donald J. McCaffrey, President & CEO of Resverlogix. “We are thrilled to be working with Dr. Provencher, and his colleagues at the Quebec Heart and Lung Institute, to help bring this life-saving treatment to market. We also want to recognize the important contribution of the IUCPQ Foundation to this work.” A primer on outcome measures used in this trial can be found HERE. A summary of the APPRoAcH-p trial design can be found HERE Next Steps: Full trial results will be presented at an upcoming scientific meeting (to be determined). The encouraging results of this study pave the way for the larger multi-centered APPRoAcH-2 trial, which is expected to begin enrolling patients later this year, and will be a phase 2, randomized, placebo-controlled study of apabetalone for the treatment of PAH. About Apabetalone Apabetalone (RVX-208), is a first-in-class, small molecule, therapeutic candidate with an epigenetic mechanism of action. It is a BD2 (bromodomain) selective BET (bromodomain and extra-terminal) inhibitor that works in preventing and treating disease progression by regulating the expression of disease-causing genes. Due to the extensive role for BET proteins in the human body, apabetalone, can simultaneously target multiple disease-related biological processes while maintaining a well-described safety profile – leading to a new way to treat chronic disease. Apabetalone received Breakthrough Therapy Designation from the US Food and Drug Administration (FDA) and is the only drug of its class with an established safety record in human clinical trials, with well over 4200 patient-years on drug across 10 clinical trials. COVID-19: Following a publication in Nature, authored by a consortium of top Universities and Research Institutions, on March 23, 2020, Resverlogix launched a COVID-19 program, conducting research internally and enlisting world-renowned collaborators. Studies – published in prestigious scientific journals (including Cell) – demonstrate that apabetalone has the potential to act against COVID-19 with a unique dual-mechanism: first by preventing viruses from entering the cells and replicating; and second by averting excessive inflammatory reactions that can cause severe and lasting organ damage. A Phase 2b clinical trial is evaluating apabetalone in combination with standard of care for patients hospitalized with COVID-19. The investigational treatment could potentially reduce the severity and duration of COVID-19. Apabetalone’s unique dual-mechanism also means that it has the potential to show efficacy against new COVID-19 variants and may even help fight other viruses. Resverlogix has partnered with EVERSANA™, the pioneer of next generation commercial services to the global life sciences industry, to support the rapid commercialization of apabetalone for COVID-19 in Canada and the United States. EVERSANA™ is currently leading clinical outreach and advocacy for apabetalone in the Canadian market. Cardiology: In February 2020, apabetalone became the first therapy of its kind to receive Breakthrough Therapy Designation from the US Food and Drug Administration (FDA) – for a major cardiovascular indication – following the ground-breaking findings from the BETonMACE Phase 3 study. Data from BETonMACE showed apabetalone can potentially prevent major adverse cardiac events among high-risk cardiovascular disease patients who also have type 2 diabetes mellitus. About Resverlogix Founded in 2001, Resverlogix is a Calgary based late-stage biotechnology company and the world leader in epigenetics, or gene regulation, with the goal of developing first-in-class therapies for the benefit of patients with chronic disease. Resverlogix is developing a new class of epigenetic therapies designed to regulate the expression of disease-causing genes. We aim to improve patients’ lives by restoring biological functions – altered by serious illnesses such as cardiovascular disease – back to a healthier state. The Company’s clinical program is focused on evaluating the lead epigenetic candidate apabetalone for the treatment of cardiovascular disease and associated comorbidities, and COVID-19. Resverlogix common shares trade on the Toronto Stock Exchange (TSX:RVX). Follow us: Twitter: @Resverlogix_RVX. LinkedIn: https://www.linkedin.com/company/resverlogix-corp-/ About the Quebec Heart and Lung Institute – IUCPQ.qc.ca Every year, 13,757* people are hospitalized and 115,654 visits were made on an outpatient basis for 41,670 users. The service area is more than 2 million people, which represents approximately 30% of Quebec’s population. Affiliated with the Laval University, the institution counts on the cooperation and the dedication of over 3,750 employees, physicians, professionals, researchers, managers as well as volunteers for providing quality care and services to both hospitalized and outpatient clienteles. In particular, the Institute offers programs of specialized and ultraspecialized care and services to treat cardiovascular and respiratory diseases as well as those related to obesity. The Institute’s physicians as well as health professionals have extensive expertise and contribute advancing the science of medicine. It also has as its mission to assess technologies and intervention methods in health. The Institute’s Research Centre is recognized internationally for the quality of its science. * 2020–2021 financial data About the IUCPQ Foundation The IUCPQ Foundation’s role is to promote and support the IUCPQ-UL’s work, whose primary mission is the health of individuals with cardiovascular, respiratory, and obesity-related diseases. The annual research competition of the IUCPQ Foundation allows many researchers to undertake and continue work for the benefit of the population and the people with cardiovascular, respiratory, and obesity-related diseases. In recent years, the foundation contributed nearly $40 million by funding the purchase of specialized equipment as well as helping to fund research and education, and this, to the greater benefit of the population in central and eastern Quebec, which represents more than 2.2 million people. About the Research Centre The Research Centre’s vision is to play an international significant role in the fight against societal chronic diseases through its model of integrated science in cardiology, in respirology as well as in obesity–type 2 diabetes–metabolism. It counts on the cooperation of 177 researchers and physicians scientists, many of whom are recognized as being leaders in their field. These world-class researchers are among the most productive in Quebec. In addition, the perfect correspondence of the research components to the Institute’s specializations ensures a synergy between clinicians and researchers, thereby allowing a rapid knowledge transfer to the care. For information about IUCPQ: Joël Clément, M.A. Communications Assistant, Human Resources and Communications Responsible for external communications and media relations Quebec Heart and Lung Institute – Laval University 418-656-4932 joel.clement@ssss.gouv.qc.ca Forward Looking Statements: This news release may contain certain forward-looking information as defined under applicable Canadian securities legislation, that are not based on historical fact, including without limitation statements containing the words "believes", "anticipates", "plans", "intends", "will", "should", "expects", "continue", "estimate", "forecasts" and other similar expressions. In particular, this news release includes forward looking information related to the Company’s APPRoAcH-2 trial, its Phase 2b COVID-19 clinical trial and the potential treatment of PAH and COVID-19 patients with apabetalone (and potentially other viruses), as well as cardiovascular disease and associated comorbidities and other chronic diseases. Our actual results, events or developments could be materially different from those expressed or implied by these forward-looking statements. We can give no assurance that any of the events or expectations will occur or be realized. By their nature, forward-looking statements are subject to numerous assumptions and risk factors including those discussed in our Annual Information Form and most recent MD&A which are incorporated herein by reference and are available through SEDAR at www.sedar.com. The forward-looking statements contained in this news release are expressly qualified by this cautionary statement and are made as of the date hereof. The Company disclaims any intention and has no obligation or responsibility, except as required by law, to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. For further information please contact: Investor Relations Email: ir@resverlogix.com Phone: 403-254-9252 www.resverlogix.com SOURCE #biotech #biotechnology #biotechnews #science #medicalscience #medicalresearch #cardiology #epigenetics #geneticresearch #epigenetictherapy #pharma #clinicaltrials #cardiovascularresearch #pennystocks #stockstowatch #biotechstocks #healthcare #apabetalone #FrontierMCG

Resverlogix in Active Discussions with The Kingdom of Morroco's Ministry of Health for the Launch of Covid-19 Clinical Studies with First-In-Class Drug Apabetalone November 1, 2021 CALGARY, Alberta, Nov. 01, 2021 (GLOBE NEWSWIRE) -- Resverlogix Corp. (“Resverlogix” or the “Company”) (TSX: RVX), a world leader in epigenetics or gene regulation, is pleased to announce today that it is in active discussions with the Kingdom of Morocco’s Ministry of Health for possible Phase 2 COVID-19 clinical studies within their hospitals using first-in-class drug – apabetalone. “We are pleased to collaborate with the Kingdom of Morocco’s Ministry of Health under the leadership of Professor Bouchra Meddah, Director of Medicines and Pharmacy, for the possible launch of COVID-19 clinical studies with our novel epigenetic drug apabetalone. It is imperative to clear hospital beds of COVID-19 patients to allow urgent surgeries and other necessities to take place, which will contribute to reopening and strengthening the economy in the Kingdom of Morocco,” said Donald J. McCaffrey, President & CEO of Resverlogix. “The Kingdom of Morocco’s Ministry of Health is pleased to be collaborating with Resverlogix on this important global initiative that has tragically impacted so many people worldwide. Our team was very impressed by the publications from Cell Journal, Nature report, along with Health Canada and FDA approvals for COVID-19 clinical trials. Our Ministry has also recognized the FDA’s granting to Resverlogix the coveted Breakthrough Therapy Designation for apabetalone in a cardiovascular indication,” said Professor Bouchra Meddah, Director of Medicines and Pharmacy – Ministry of Health in the Kingdom of Morocco. Following Health Canada’s approval for Resverlogix’s COVID-19 clinical trials, it has been actively working with hospitals and ministries to commence COVID-19 trials globally. On October 12th, 2021, Resverlogix received ethics committee approval for COVID-19 clinical trials in Western Canadian sites. Additionally, a Phase 3 COVID-19 trial in the US is anticipated to commence in coming months based on final protocol approval. Phase 2 Trial Overview– Canada/Brazil Study participants will be made up of patients hospitalized with confirmed COVID-19 cases. Participants will either receive twice daily doses of apabetalone for up to 4 weeks alongside standard of care, compared to standard of care alone. The primary outcome measure of the study will be change in the World Health Organization (WHO) Ordinal Scale for Clinical Improvement. A total of 100 patients are expected to be enrolled at multiple sites in Canada and Brazil. The full study protocol can be found on clinicaltrials.gov. About Apabetalone Apabetalone (RVX-208), is a first-in-class, epigenetic small molecule, or gene regulating, therapeutic candidate. It is a selective BET (bromodomain and extra-terminal) inhibitor, which works in preventing disease by turning genes on and/or off through regulation of gene expression. The prevalence of BET proteins in the human body allows apabetalone, through its unique mechanism of action, to simultaneously target multiple disease-causing biological processes while maintaining a well described safety profile – leading to a new way to treat chronic disease. Cardiology: In February 2020, apabetalone became the first therapy of its kind to receive Breakthrough Therapy Designation by the US Food and Drug Administration (FDA) – for a major cardiovascular indication – following the ground-breaking findings from the BETonMACE Phase Three study. Data from BETonMACE showed apabetalone can potentially prevent major adverse cardiac events among high-risk cardiovascular disease patients who also have type 2 diabetes mellitus. Covid-19: On March 23, 2020, Resverlogix launched its COVID-19 program, enlisting world-renowned collaborators. Studies demonstrate that apabetalone has the potential to act against COVID-19 with a unique dual-mechanism: the first pillar of apabetalone’s dual-mechanism is preventing viruses from entering the cells and replicating; the second pillar is averting runaway inflammatory reactions that can cause severe and lasting organ damage. A Phase Two clinical trial is evaluating apabetalone in combination with standard of care for patients hospitalized with COVID-19. Apabetalone treatment could potentially reduce the severity and duration of COVID-19. Apabetalone’s unique dual-mechanism also means that it is likely to show efficacy against COVID-19 variants and may even help fight other related viruses. Apabetalone is the only drug of its class with a well-established safety record in human clinical trials, with well over 4200 patient-years on drug across 10 clinical trials. About Resverlogix Founded in 2001, Resverlogix is a Calgary based late-stage biotechnology company and the world leader in epigenetics, or gene regulation, with the goal of developing first-in-class therapies for the benefit of patients with chronic disease. Resverlogix is commercializing a new class of epigenetic therapies designed to regulate gene expression, turning disease-associated genes “on” or “off”. We aim to improve patients’ lives by restoring biological functions – altered by serious illnesses such as cardiovascular disease – back to a healthier state. The Company’s clinical program is focused on evaluating the lead epigenetic candidate apabetalone for the treatment of cardiovascular disease and associated comorbidities, and COVID-19. Resverlogix common shares trade on the Toronto Stock Exchange (TSX:RVX). Follow us: Twitter: @Resverlogix_RVX. LinkedIn: https://www.linkedin.com/company/resverlogix-corp-/ Forward Looking Statements: This news release may contain certain forward-looking information as defined under applicable Canadian securities legislation, that are not based on historical fact, including without limitation statements containing the words "believes", "anticipates", "plans", "intends", "will", "should", "expects", "continue", "estimate", "forecasts" and other similar expressions. In particular, this news release includes forward looking information related to the Company’s discussions with the Kingdom of Morocco’s Ministry of Health, the Company’s clinical trials and the potential role of Apabetalone in the treatment of patients with COVID-19 (and potentially other viruses), cardiovascular disease and associated comorbidities and other chronic diseases. Our actual results, events or developments could be materially different from those expressed or implied by these forward-looking statements. We can give no assurance that any of the events or expectations will occur or be realized. By their nature, forward-looking statements are subject to numerous assumptions and risk factors including those discussed in our Annual Information Form and most recent MD&A which are incorporated herein by reference and are available through SEDAR at www.sedar.com. The forward-looking statements contained in this news release are expressly qualified by this cautionary statement and are made as of the date hereof. The Company disclaims any intention and has no obligation or responsibility, except as required by law, to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. For further information please contact: Investor Relations Email: ir@resverlogix.com Phone: 403-254-9252 www.resverlogix.com A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/37e766e7-6988-45b9-b572-a129fcd3b126 SOURCE #biotech #biotechnews #apabetalone #covid19 #covidresearch #clinicaltrials #medicalresearch #biotechstocks #stockstowatch #pennystocks #FrontierMCG

VANCOUVER, British Columbia, Oct. 21, 2021 (GLOBE NEWSWIRE) — Rakovina Therapeutics Inc. (TSXV: RKV) ("the Company"), a biopharmaceutical company committed to advancing new cancer therapies based on novel DNA-damage response technologies, today announced that the Company has been invited to present a poster presentation at the sixth biennial Canadian Cancer Research Conference (CCRC), which is being held virtually November 8-11, 2021. The CCRC brings together the cancer research community for an agenda spanning the oncology research spectrum and presents an opportunity for researchers, trainees, clinicians, decision-makers, and patients to hear the latest developments in Canadian cancer research and network across multiple research disciplines. During the meeting, Rakovina Therapeutics researchers will present an update on lead optimization activities with the Company’s novel kt-3000 series. The kt-3000 series drug candidates combine potent inhibition of histone deacetylase (HDAC) and poly (ADP-ribose) polymerase (PARP) in a single molecule. PARP-inhibitors have recently become important in the treatment of certain cancers including BRCA-mutant breast, ovarian and prostate cancers. Rakovina Therapeutics is researching the kt-3000 series potential to overcome cancer cells’ development of resistance to PARP-inhibitor therapy. Further information and registration details for the CCRC can be found at https://www.ccra-acrc.ca/conference/ About Rakovina Therapeutics Inc. Rakovina Therapeutics Inc. is focused on the development of new cancer treatments based on novel DNA-damage response technologies. The Company has established a pipeline of DNA-damage response inhibitors with the goal of advancing one or more drug candidates into human clinical trials and obtaining marketing approval for new cancer therapeutics from Health Canada, the United States Food and Drug Administration and similar international regulatory agencies. Further information may be found at www.rakovinatherapeutics.com. Additional Information The TSXV has neither approved nor disapproved the content of this press release. Neither the TSXV nor its Regulation Services Provider (as that term is defined in policies of the TSXV) accepts responsibility for the adequacy or accuracy of this release. Notice regarding forward-looking statements: This release includes forward-looking statements regarding the Company and its respective business, which may include, but is not limited to, statements with respect to the proposed business plan of the Company and other statements. Often, but not always, forward-looking statements can be identified by the use of words such as “plans”, “is expected”, “expects”, “scheduled”, “intends”, “contemplates”, “anticipates”, “believes”, “proposes” or variations (including negative variations) of such words and phrases, or state that certain actions, events, or results “may”, “could”, “would”, “might” or “will” be taken, occur or be achieved. Such statements are based on the current expectations of the management of the Company. The forward-looking events and circumstances discussed in this release may not occur by certain specified dates or at all and could differ materially as a result of known and unknown risk factors and uncertainties affecting the Company, including risks regarding the medical device industry, economic factors, regulatory factors, the equity markets generally and risks associated with growth and competition. Although the Company has attempted to identify important factors that could cause actual actions, events, or results to differ materially from those described in forward-looking statements, there may be other factors that cause actions, events, or results to differ from those anticipated, estimated or intended. No forward-looking statement can be guaranteed. Except as required by applicable securities laws, forward-looking statements speak only as of the date on which they are made and the Company undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events, or otherwise. The reader is referred to the Company’s most recent filings on SEDAR for a more complete discussion of all applicable risk factors and their potential effects, copies of which may be accessed through the Company’s profile page at www.sedar.com. Contact: Rakovina Therapeutics Inc. David Hyman Chief Financial Officer Email: info@rakovinatherapeutics.com Investor Relations Contact IR@rakovinatherapeutics.com Media Contact MEDIA@rakovinatherapeutics.com #biotech #biotechnews #cancer #cancerresearch #CanadianCancerResearch #medicalresearch #biotechstocks #stockstowatch #pennystocks #FrontierMCG

Rakovina Therapeutics Presents at the 2021 AACR- NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics Presentation highlights pre-clinical data from Rakovina Therapeutics’ novel kt-3000 series dual PARP-HDAC inhibitors VANCOUVER, BC, October 12, 2021 /CNW/ - Rakovina Therapeutics Inc. (TSXV: RKV) ("the Company"), a biopharmaceutical company committed to advancing new cancer therapies based on novel DNA-damage response (DDR) technologies, today announced a summary of the Company’s presentation at the 2021 AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics, which was held virtually on October 7-10, 2021. Rakovina Therapeutics presented a video presentation entitled In Vitro Activity of Novel kt-3000 Series Dual PARP-HDAC Inhibitors. The kt-3000 series are novel drug candidates that combine inhibition of poly (ADP-ribose) polymerase (PARP) and histone deacetylase (HDAC) into a single molecule. “PARP inhibitors are an established treatment against tumor phenotypes harboring deficiencies in homologous DNA repair (HR) and have led to improved clinical outcomes for patients with HR- deficient ovarian, breast and prostate cancers,” said Jeffrey Bacha, executive chairman of Rakovina Therapeutics. “Unfortunately, the emergence of clinical resistance to PARP-inhibitor treatment has become an important unmet medical need in the fight against these cancers.” An established mechanism of resistance to PARP inhibitors involves the restoration of BRCA1 or BRCA2 – genes that are important in fighting cancer. Patients with BRCA mutations have a reduced ability to repair DNA damage and therefore are at a higher risk of developing certain types of cancer compared to someone who doesn’t have a BRCA mutation. PARP-inhibitors target cancer cells with BRCA mutations by taking advantage of their reduced DNA-repair capacity to selectively kill cancer cells. When a cancer cell is able to restore BRCA function, PARP-inhibitors become less effective. Laboratory studies demonstrate that HDAC inhibition degrades BRCA1 in cells that have become resistant to PARP inhibitors, which has been shown to re-sensitize resistant cancers to PARP- inhibitor treatment. HDAC inhibition also induces PARP activity, which suggests the potential for treatment synergy in combining an HDAC inhibitor with a PARP inhibitor. While this concept has demonstrated promise in the laboratory, translation to a clinical setting has proved challenging due to overlapping toxicities and differing pharmacokinetics. Rakovina Therapeutics kt-3000 series combines HDAC and PARP inhibitor in a single molecule, which the Company believes may offer a viable approach to providing this important combination treatment to overcome PARP-inhibitor resistance in patients. Data presented at the conference demonstrate that select kt-3000 series compounds exhibit strong inhibition of both PARP and HDAC comparable to FDA-approved single-target PARP and HDAC inhibitors. “We are pleased to report continued progress in the development of the kt-3000 series as a potential next-generation approach in the emerging field of DNA-damage response inhibitors. As a next step, we plan to advance the most promising lead compounds from this series into in vivo studies,” said Prof. Mads Daugaard, president and chief scientific officer of Rakovina Therapeutics. “We look forward to continuing to report our progress at upcoming scientific meetings.” About Rakovina Therapeutics Inc. Rakovina Therapeutics Inc. is focused on the development of new cancer treatments based on novel DNA-damage response (DDR) technologies. The Company has established a pipeline of DNA-damage response inhibitors with the goal of advancing one or more drug candidates into human clinical trials and obtaining marketing approval for new cancer therapeutics from Health Canada, the United States Food and Drug Administration and similar international regulatory agencies. Further information may be found at www.rakovinatherapeutics.com. Additional Information The TSXV has neither approved nor disapproved the content of this press release. Neither the TSXV nor its Regulation Services Provider (as that term is defined in policies of the TSXV) accepts responsibility for the adequacy or accuracy of this release. Notice regarding forward-looking statements: This release includes forward-looking statements regarding the Company and its respective business, which may include, but is not limited to, statements with respect to the proposed business plan of the Company and other statements. Often, but not always, forward-looking statements can be identified by the use of words such as “plans”, “is expected”, “expects”, “scheduled”, “intends”, “contemplates”, “anticipates”, “believes”, “proposes” or variations(including negative variations) of such words and phrases, or state that certain actions, events, or results “may”, “could”, “would”, “might” or “will” be taken, occur or be achieved. Such statements are based on the current expectations of the management of the Company. The forward-looking events and circumstances discussed in this release may not occur by certain specified dates or at all and could differ materially as a result of known and unknown risk factors and uncertainties affecting the Company, including risks regarding the medical device industry, economic factors, regulatory factors, the equity markets generally and risks associated with growth and competition. Although the Company has attempted to identify important factors that could cause actual actions, events, or results to differ materially from those described in forward-looking statements, there may be other factors that cause actions, events, or results to differ from those anticipated, estimated or intended. No forward-looking statement can be guaranteed. Except as required by applicable securities laws, forward-looking statements speak only as of the date on which they are made and the Company undertakes no obligation to publicly update or revise any forward- looking statement, whether as a result of new information, future events, or otherwise. The reader is referred to the Company’s most recent filings on SEDAR for a more complete discussion of all applicable risk factors and their potential effects, copies of which may be accessed through the Company’s profile page at www.sedar.com. Contact: Rakovina Therapeutics Inc. David Hyman Chief Financial Officer Email: info@rakovinatherapeutics.com Investor Relations Contact IR@rakovinatherapeutics.com Media Contact MEDIA@rakovinatherapeutics.com SOURCE #biotech #biotechnews #cancer #cancerresearch #medicalresearch #drugdevelopment #clinicaltrials #biotechstocks #stockstowatch #FrontierMCG

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VANCOUVER, British Columbia, Nov. 23, 2022 (GLOBE NEWSWIRE) -- Rakovina Therapeutics Inc. (TSX-V: RKV) (“Rakovina” or the “Company”), a biopharmaceutical company committed to advancing new cancer therapies based on novel DNA-damage response (DDR) technologies, is pleased to announce that it has been invited to present at the Emerging Growth Conference on Wednesday, November 30, 2022, at 10:15am Eastern standard time. Rakovina invites individual and institutional investors as well as advisors and analysts, to attend its real-time, interactive on-line presentation at the Emerging Growth Conference. This live, interactive online event will give existing shareholders and the investment community the opportunity to interact with the Company’s management. Rakovina Therapeutics’ management will deliver a brief corporate overview and then be available for questions and discussions with conference participants. Rakovina Therapeutics will be presenting at 10:15AM Eastern time for 30 minutes. Please register here to ensure you are able to attend the conference and receive any updates that are released. https://goto.webcasts.com/starthere.jsp?ei=1575088&tp_key=b1fead5049&sti=rkv If attendees are not able to join the event live on the day of the conference, an archived webcast will also be made available on EmergingGrowth.com About the Emerging Growth Conference The Emerging Growth conference provides an efficient platform for public companies to present and communicate their new products, services and other announcements to the investment community from the convenience of their office, in a time efficient manner. The Conference focus and coverage includes companies in a wide range of growth sectors, with strong management teams, innovative products & services, focused strategy, execution, and the overall potential for long term growth. Its audience includes potentially tens of thousands of Individual and Institutional investors, as well as Investment advisors and analysts. About Rakovina Therapeutics Inc. Rakovina Therapeutics Inc. is focused on the development of new cancer treatments based on novel DNA-damage response (DDR) technologies. The Company has established a pipeline of novel DNA-damage response inhibitors with the goal of advancing one or more drug candidates into human clinical trials and obtaining marketing approval for new cancer therapeutics from Health Canada, the United States Food and Drug Administration and similar international regulatory agencies. Further information may be found at www.rakovinatherapeutics.com. Additional Information The TSXV has neither approved nor disapproved the content of this press release. Neither the TSXV nor its Regulation Services Provider (as that term is defined in policies of the TSXV) accepts responsibility for the adequacy or accuracy of this release. Notice regarding forward-looking statements: This release includes forward-looking statements regarding the Company and its respective business, which may include, but is not limited to, statements with respect to the proposed business plan of the Company and other statements. Often, but not always, forward-looking statements can be identified by the use of words such as “plans”, “is expected”, “expects”, “scheduled”, “intends”, “contemplates”, “anticipates”, “believes”, “proposes” or variations (including negative variations) of such words and phrases, or state that certain actions, events, or results “may”, “could”, “would”, “might” or “will” be taken, occur or be achieved. Such statements are based on the current expectations of the management of the Company. The forward-looking events and circumstances discussed in this release may not occur by certain specified dates or at all and could differ materially as a result of known and unknown risk factors and uncertainties affecting the Company, including risks regarding the medical device industry, economic factors, regulatory factors, the equity markets generally and risks associated with growth and competition. Although the Company has attempted to identify important factors that could cause actual actions, events, or results to differ materially from those described in forward-looking statements, there may be other factors that cause actions, events, or results to differ from those anticipated, estimated or intended. No forward-looking statement can be guaranteed. Except as required by applicable securities laws, forward-looking statements speak only as of the date on which they are made and the Company undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events, or otherwise. The reader is referred to the Company’s most recent filings on SEDAR for a more complete discussion of all applicable risk factors and their potential effects, copies of which may be accessed through the Company’s profile page at www.sedar.com. Contact: Rakovina Therapeutics Inc. David Hyman Chief Financial Officer Email: info@rakovinatherapeutics.com Investor Relations Contact IR@rakovinatherapeutics.com Media Contact MEDIA@rakovinatherapeutics.com SOURCE